Photo: Fred Hutch
Education, Training, Board Certifications
- M.D., University of Washington
- Ph.D., University of Washington
- Residency, Massachusetts General Hospital
- Fellowship in Medical Oncology, Dana Farber Cancer Institute
- Fellowship in Computational Biology, MIT-Whitehead Center for Genomic Research
- Internal Medicine, American Board of Internal Medicine
Clinical Expertise
- Proteomics
- Genetics
- Adult Oncology
Affiliations
Publications
Research and/or clinical interests
Dr. Amanda Paulovich is a leader in proteomics, the study of proteins — the cell’s workhorse molecules. Due to a lack of tools, proteomics has lagged behind the study of genes, which provide the blueprints for proteins. And just as a blueprint cannot tell you everything about a finished house, our genetic blueprint only reveals part of the biological picture. By developing powerful protein-measuring tools, Dr. Paulovich helps to fill in this picture and open the door to treatments tailored to individual cancer patients.
Her team has spearheaded the development of assays that use a technique called multiple reaction monitoring mass spectrometry, or MRM-MS, to detect and precisely measure the amount of a particular protein. This technology will help researchers combine detailed information about proteins with genetic data to learn, for instance, which genetic mutations drive a cancer’s development and suggest and characterize new therapeutic targets.
